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Knockdown of DJ-1 eliminated the protective effect of IPo on the intestine against myocardial IR, as evidenced by increased intestinal oxidative stress and exacerbated intestinal epithelial cell apoptosis. The implications of our current study may be enormous as organ crosstalk occurs all the time under pathophysiological conditions. Although our results show that IPo is of great value for preventing AMI and myocardial-induced intestinal injury, it is still challenging to translate this approach into clinical applications.

This study also has some limitations. Our animal experiment used reductionist approaches and was performed in young and healthy rats that lacked the risk factors, comorbidities, and comedications which are the characteristics of patients suffering from AMI or undergoing PCI or cardiovascular surgery. Advanced age, diabetes, hypertension, and hypercholesterolemia all interfere with cardioprotective interventions and attenuate or abrogate infarct size reduction induced by IPo.

In the future, our group will add relevant risk factors like diabetes to verify the protective effect of IPo. In summary, our data demonstrated that IPo protects against the myocardial IR-induced intestinal injury. Q-tM and Z-yX contributed to conception and design of the study.

QZ performed the statistical analysis. RC wrote the first draft of the manuscript. All authors contributed to manuscript revision, and read and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

B serum CK-MB level. G Expression of DJ-1 level. Amatullah, H. Care Med. Billia, F. Bonifati, V. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science , — Brown, J. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases.

Bulluck, H. Reducing myocardial infarct size: challenges and future opportunities. Heart , — Cao, S. Ischemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts. PeerJ 4:e Chen, R. Ischemic postconditioning attenuates acute kidney injury following intestinal ischemia-reperfusion through Nrf2-regulated autophagy, anti-oxidation, and anti-inflammation in mice. Cheng, Y. Free Radic. Chiu, C. Intestinal mucosal lesion in low-flow states.

A morphological, hemodynamic, and metabolic reappraisal. Clements, C. Dongworth, R. DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury. Cell Death Dis. Fan, J. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. Gao, W. Acta Cir. Hao, M. Hausenloy, D. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. Heusch, G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning.

Critical issues for the translation of cardioprotection. The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Heart J. Kalder, J. Microcirculatory perfusion shift in the gut wall layers induced by extracorporeal circulation. Kitakaze, T. Kushner, F. Circulation , — Lam, V.

Intestinal microbial metabolites are linked to severity of myocardial infarction in rats. PLoS One e Leary, S. Google Scholar. Li, W. Liu, Z. Gene Lu, H. Cell Biochem. Mao, Y. Intestinal barrier function in patients with acute myocardial infarction and the therapeutic effect of glutamine.

Meng, Q. Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: role of Nrf2. Nagatomo, Y. Intersections between microbiome and heart failure: revisiting the gut hypothesis. Fail 21, — Neri, M. Mediators Inflamm Pagliaro, B. Myocardial ischemia and coronary disease in heart failure. Heart Fail Rev. Qiu, Z. Cell Longev. Repici, M.

Seropian, I. Inflammatory markers in ST-elevation acute myocardial infarction. Acute Cardiovasc. Care 5, — Shahzad, T. Mechanisms involved in postconditioning protection of cardiomyocytes against acute reperfusion injury. Cell Cardiol. Shimizu, Y. DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission.

Stoian, L. Acta Mol. Basis Dis. Takala, J. Determinants of splanchnic blood flow. Vavougios, G. Wang, S. Cardiac vagal reflex modulates intestinal vascular capacitance and ventricular preload in anesthetized dogs with acute myocardial infarction. Circulation 94, — Wang, T. Overexpression of inducible nitric oxide synthase in the diabetic heart compromises ischemic postconditioning.

Wang, W. Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine 23, — DJ-1 protects retinal pericytes against high glucose-induced oxidative stress through the Nrf2 signaling pathway. Wang, X. Wu, Z. The changes of gut microbiota after acute myocardial infarction in rats.

Xin, L. Overexpression of DJ-1 expression protects cardiomyocyte apoptosis induced by ischemia reperfusion. Xu, B. Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1. Xue, R. Yanagisawa, D. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. Blood Flow Metab. Zeng, J. Eye Res. Zhang, J. Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p Zhang, X.

DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult. Zhao, Z. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Heart Circ.

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MyoKardia, a developer of targeted therapies for the treatment of rare cardiovascular diseases, has raised $ million in its IPO. MyoKardia is registered under the ticker NASDAQ:MYOK. Their stock opened with $ in its Oct 29, IPO. MyoKardia. MyoKardia goes public well below targets, IPO raises $54M MyoKardia, led by CEO Tassos Gianakakos, raised $54 million in an IPO that priced.